Unveiling hemodynamic pulsatile flow dynamics in carotid artery stenosis: Insights from computational fluid dynamics

Parent resource - Cardiovascular Fluid Dynamics Project (BTP I & II)

DOI - 10.1063/5.0216867
Journal Name - AIP Advances
Publisher Name - AIP Publishing
Document Type - journal-article

Paper Abstract- This paper presents a comprehensive model of hemodynamic pulsatile flow within the carotid artery, examining both normal conditions and those affected by stenosis. The primary focus lies in visualizing shear stress along the inner walls, aiming to elucidate how stenosis alters blood flow characteristics and subsequently impacts plaque deposition. Utilizing advanced computational fluid dynamics simulations, temporal variations in flow patterns, velocity profiles, and pressure gradients resulting from stenosis are captured, thereby elucidating the mechanical forces exerted on arterial walls. Moreover, this study analyzes the influence of hemodynamic parameters, such as Reynolds number, Womersley number, and arterial geometry, on flow disruption and stagnation points. Such insights are critical in understanding the mechanisms underlying plaque formation and progression. Critical thresholds of shear stress and flow patterns contributing to endothelial dysfunction and atherosclerotic lesion initiation are identified by comparing hemodynamic environments in healthy vs stenotic arteries. The results demonstrate significant differences in hemodynamic characteristics between stenosed and normal arteries, particularly near systolic peaks. Stenosed arteries exhibit notably higher velocities at arterial bifurcations during systole than normal arteries, indicative of altered flow dynamics. In addition, stenosis disrupts flow patterns, leading to vortex formation at locations beyond systolic peaks. Overall, findings from this research advance our understanding of cardiovascular disease pathogenesis and provide valuable insights into the hemodynamic effects of arterial stenosis.